Alain Stricker-Krongrad, Ph.D., Senior Vice President of Science and Business Development

Professional Summary:

Dr. Stricker-Krongrad is Senior Vice President of Science and Business Development at BRM with over 20 years of experience in pharmacology and preclinical research. He is responsible for overseeing scientific, governmental and contractual preclinical research and will guide BRM/Biomere during the national expansion phase of its business.

Since 2008 he served as Chief Scientific Officer of Charles River Laboratories (CRL) and helped advance key science-based programs and helped foster science-related initiatives and capabilities. From 2006 to 2008 he was the director and head of preclinical safety and pharmacology at CRL, Preclinical Services. During his tenure he developed short- and long-term strategic plans for new technologies and services and was in charge of the non-clinical evaluation (efficacy and safety) of synthetics, biologics, cell-based products, devices and surgical products. He also held managerial positions at Millennium Pharmaceuticals and Athersys, in the U.S. and Novartis Headquarters in Switzerland. He obtained his Ph.D. in Pharmacology at the University of Henri Poincare (France), his Post-Doctoral training at INSERM, where he received two international awards for his research and conducted his Post-Graduate training in Clinical Pharmacology, Drug Development and Regulation at Tufts University. He has published more than 60 peer-reviewed papers and is a member of the Editorial Board of Expert Opinion in Drug Discovery.

Publications:

Beck B., Stricker-Krongrad A., Nicolas J.P., Burlet C. Chronic and continuous ICV infusion of neuropeptide Y disrupts the nycthemeral feeding patterns in rats. Ann. N.Y. Acad. Sci. 1990, 611, 491-494.

Beck B., Stricker-Krongrad A., Burlet A., Nicolas J.P., Burlet C. Influence of diet composition on food intake and hypothalamic neuropeptide Y (NPY) in the rat. Neuropeptides. 1990, 17, 197-203

Beck B., Stricker-Krongrad A., Burlet A., Nicolas J.P., Burlet C. Changes in hypothalamic neurotensin concentrations and food intake in rats fed a high fat diet. Int. J. Obesity. 1992, 16, 361-366

Beck B., Stricker-Krongrad A., Nicolas J.P., Burlet C. Chronic and continuous intracerebroventricular infusion of neuropeptide Y in Long-Evans rats mimics the feeding behavior of obese Zucker rats. Int. J. Obesity. 1992, 16, 295-302

Beck B., Stricker-Krongrad A., Burlet A., Nicolas J.P., Burlet C. Specific hypothalamic neuropeptide Y variation with diet parameters in rats with food choice Neuroreport. 1992, 3, 571-574

Stricker-Krongrad A., Beck B., Nicolas J.P., Burlet C. Central effects of monosodium glutamate on feeding behavior in adult Long-Evans rats. Pharmacol. Biochem. Behav. 1992, 43, 881-886

Stricker-Krongrad A., Beck B., Max J.P., Nicolas J.P., Burlet C. Intracerebroventricular injection of monosodium-glutamate (MSG) stimulates food intake in Long Evans rats. In "Obesity in Europe 1991" G. AILHAUD, B. GUY-GRAND, M. LAFONTAN, D. RICQUIER Eds., John Libbey (London), 1992, pp.51-54

Stricker-Krongrad A., Barbanel G., Beck B., Burlet A., Nicolas J.P., Burlet C. K+- stimulated neuropeptide Y release into the paraventricular nucleus and relation to feeding behavior in free-moving rats. Neuropeptides. 1993, 24, 307-312 Stricker-Krongrad A., Beck B., Nicolas J.P., Burlet C. The pros and cons in the use of intracerebral microdialysis and push-pull perfusion for harvesting heavy weight extracellular compounds : a study with neuropeptide Y. Curr. Separations. 1993, 12, 78

Mertes P.M., Beck B., Jaboin Y., Stricker-Krongrad A., Carteaux J.P., Pinelli G., El Abassi K., Villemot J.P., Burlet C. Boulanger M. Microdialysis to estimate myocardal interstitial neuropeptide Y release. Reg. Pept. 1993, 49, 81-90.

Beck B., Stricker-Krongrad A., Burlet A., Nicolas J.P., Burlet C. Macronutrient type independently of energy intake modulates hypothalamic neuropeptide Y (NPY) in Long-Evans rats. Brain Res. Bull. 1994, 34, 2, 85-91.

Stricker-Krongrad A., Max J.P., Musse N., Nicolas J.P., Burlet C, Beck B. Increased threshold concentrations of neuropeptide Y for a stimulatory effect on food intake in obese Zucker rats - changes in the microstructure of the feeding behavior. Brain Res. 1994, 660, 162-166.

Beck B., Stricker-Krongrad A., Musse N., Nicolas J.P., Burlet C. Putative neuropeptide Y antagonist failed to decrease overeating in obese Zucker rats. Neurosci. Letters. 1994, 181, 126-128.

Stricker-Krongrad A., Beck B., Burlet C. Microdialysis and push-pull perfusion to estimate hypothalamic paraventricular neuropeptide Y release. in Monitoring Molecules in Neuroscience. 1994 (A. Louilot, T. Durkin, U. Spampinato, M. Cador. Eds), 354-355.

Mertes P.M., El Abassi K., Beck B., Jaboin Y., Carteaux J.P., Pinelli G., Stricker-Krongrad A., Villemot J.P., Burlet C. Interstitial myocardial norepinephrine and neuropeptide Y release following coronary occlusion. in Monitoring Molecules in Neuroscience. 1994 (A. Louilot,T. Durkin, U. Spampinato, M. Cador. Eds), 352-353.

Stricker-Krongrad A., Beck B., Burlet C. Nitric oxide mediates hyperphagia of obese Zucker rats: relation to specific changes in the microstructure of feeding behavior. Life Sciences (Pharmacol. Letters). 1995, 58 (1), 9-15.

Stricker-Krongrad A., Beck B., Burlet C. Enhanced feeding response to neuropeptide Y in hypothalamic neuropeptide Y-depleted rats. Eur. J. Pharmacol. 1996, 295, 27-34.

Lluch A., Kahn J.P., Stricker-Krongrad A., Ziegler O., Droin P., Mejean L. Internal validation in French of the Dutch Eating Behavior Questionnaire. European Psychiatry. 1996, 11, 198-203.

Cusin I., Rhoner-Jeanrenaud F., Stricker-Krongrad A., Jeanrenaud B. Weight-reducing effect of intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats: reduced sensitivity compared to lean animals. Diabetes. 1996, 45, 1446-1450.

Mejean L, Stricker-Krongrad A., Lluch A. Chronobiology, nutrition and metabolism. Pathologie et Biologie. 1996, 44, 603-609.

Mejean L, Stricker-Krongrad A., Lluch A. The endocrine system and diabetes. in Handbook of Experimental Pharmacology. Editors: P.H. Redfern and B. Lemmer, Springer-Verlag Berlin 1997, 125, Chapter 12, 333-350.

Beck B., Stricker-Krongrad A., Burlet A., Musse N., Nicolas J.P., Burlet C. Dietary preferences in monosodium glutamate-lesioned rats: age-variable influence of hypothalamic neuropeptide Neurosci. Letters. 1997, 225, 153-156.

Schaffhauser A., Stricker-Krongrad A., Brunner L., Cumin F., Gerald C., Whitebread S., Criscione L., Hofbauer K.G. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides. Diabetes.1997, 46, 1792-1798.

Lollmann B., Gruninger S., Stricker-Krongrad A., Chiesi M. Detection and quantification of the leptin receptor splice variants Ob-Ra, b and e in different mouse tissues. BBRC. 1997, 238, 648-652.

Brunner L., Nick Hp., Cumin F., Chiesi M., Baum Hp., Whitebread S., Stricker-Krongrad A., Levens N. Leptin is a physiologicaly important regulator of food intake. Int. J Obesity, 1997, 21, 1152-1160.

Stricker-Krongrad A., Kozak R., Beck B., Nicolas J.P., Burlet C. Physiological regulation of neuropeptide Y release in lean and obese Zucker rats. Am. J. Physiol. 1997, 273, 42, R2112-R216.

Beck B., Kozak R., Stricker-Krongrad A., Burlet C. Neuropeptide Y release in the paraventricular nucleus of Long-Evans rats treated with leptin. BBRC. 1998, 242, 636-639.

Stricker-Krongrad A., Burlet C, Beck B. Behavioral deficits in the monosodium glutamate rat: specific changes in the structure of feeding behavior. Life Sciences. 1998, 62, 2127-2132.

Stricker-Krongrad A., Burlet A., Nicolas J.P., Burlet C., Beck B. Neuropeptide Y in the ventromedial and suprachiasmatic nuclei and feeding pattern in monosodium glutamate-treated rats. Nutr. Neurosci. 1998, 1, 183-189.

Wyss P., Levens N, Stricker-Krongrad A. Stimulation of feeding in lean but not obese Zucker rats by a selective neuropeptide Y Y5 receptor agonist. Neuroreport. 1998, 9, 2675-2677.

Stricker-Krongrad A., Burlet C, Beck B. Hypothalamic neuropeptide Y and plasma leptin after long-term high-fat feeding in the rat. Neuroscience Letters. 1998, 254(3):157-160.

Schaffhauser A., Whitebread S., Haener R., Hofbauer K.G., Stricker-Krongrad A. Neuropeptide Y Y1 receptor antisense oligodeoxynucleotides enhance food intake in energy-deprived rats. Regulatory Peptides, 1998, 75-6:417-423.

Wyss P., Stricker-Krongrad A., Brunner L., Crossthwaite A., Whitebread S., Criscione L. The pharmacology of neuropeptide Y receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes. Regulatory Peptides. 1998, 75-6:363-371.

Beck B., Stricker-Krongrad A., Richy S., Burlet C. Evidence that hypothalamic neurotensin signals leptin effects on feeding behavior in normal and fat-preferring rats. Biochemical & Biophysical Research Communications. 1998, 252(3):634-638.

Lubkin M., Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochemical & Biophysical Research Communications. 1998, 253(2):241-245.

Criscione L., Rigollier P., Batzl-Hartmann C., Rueger H., Stricker-Krongrad A., Wyss P., Brunner L., Whitebread S., Yamaguchi Y., Gerald C., Heurich RO., Walker MW., Chiesi M., Schilling W., Hofbauer KG., Levens N. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y-5 receptor. Journal of Clinical Investigation. 1998, 102(12):2136-2145.

Zakrzewska KE., Cusin I., Stricker-Krongrad A., Boss O., Ricquier D., Jeanrenaud B., Rohner-Jeanrenaud F. Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat. Diabetes. 1999, 48(2):365-370.

Brunner L, Whitebread S, Leconte I, Stricker-Krongrad A., Cumin F, Chiesi M, Levens N. A peptide leptin antagonist reduces food intake in rodents. Int J Obes Relat Metab Disord. 1999, May;23(5):463-9.

Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe H, Stricker-Krongrad A., Shulman GI, Neel BG, Kahn BB. Increased energy expenditure, decreased adiposity and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B (PTP-1B)-deficient mice. Mol Cell Biol. 2000, Aug;20(15):5479-89.

Schaffhauser AO, Stricker-Krongrad A., Hofbauer KG. NPY Y5 receptor subtype. Pharmacological characterization with antisense oligodeoxynucleotide screening strategy. Methods Mol Biol. 2000.153:129-50.

White DW, Zhou J, Stricker-Krongrad A., Ge P, Morgenstern JP, Dembski M, Tartaglia LA. Identification of leptin-induced transcripts in the mouse hypothalamus. Diabetes. 2000 Sep. 49(9):1443-50.

Beck B, Stricker-Krongrad A., Burlet A, Cumin F, Burlet C. Plasma leptin and hypothalamic neuropeptide Y and galanin levels in Long-Evans rats with marked dietary preferences. Nutr. Neurosci. 2001, 4, 39-50.

Stricker-Krongrad A., Dimitrov T., Beck B. Central and peripheral dysregulation of melanin-concentrating hormone in obese Zucker rats. Mol. Brain Res. 2001. 92, 43-48.

Beck B, Richy S, Dimitrov T, Stricker-Krongrad A. Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker rats. Biochem Biophys Res Commun. 2001. Aug 24;286(3):518-23.

Stricker-Krongrad A., Richy S, Beck B. Orexins/hypocretins in the ob/ob mouse: hypothalamic gene expression, peptide content and metabolic effects. Regul Pept. 2002 Mar 15;104(1-3):11-20.

Beck B, Burlet A, Max JP, Stricker-Krongrad A. Effects of long-term ingestion of aspartame on hypothalamic neuropeptide Y, plasma leptin and body weight gain and composition. Physiol Behav. 2002 Feb 1-15;75(1-2):41-7.

Beck B, Musse N, Stricker-Krongrad A., Ghrelin, macronutrient intake and dietary preferences in long-evans rats. Biochem Biophys Res Commun. 2002 Apr 12;292(4):1031-5.

Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A., Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG. PTP1B regulates leptin signal transduction in vivo. Dev Cell. 2002 Apr;2(4):489-95.

Ogier V, Ziegler O, Mejean L, Nicolas JP, Stricker-Krongrad A. Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans. Int J Obes Relat Metab Disord. 2002 Apr;26(4):496-503.

Stricker-Krongrad A., Beck B. Modulation of hypothalamic hypocretin/orexin mRNA expression by glucocorticoids. Biochem Biophys Res Commun. 2002 Aug;296(1):129-33.

Gimeno RE, Hirsch DJ, Punreddy S, Sun Y, Ortegon AM, Wu H, Daniels T, Stricker-Krongrad A., Lodish HF, Stahl A. Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem. 2003 Dec 5;278(49):49512-6.

Beck B, Richy S, Stricker-Krongrad A. Ghrelin and body weight regulation in the obese Zucker rat in relation to feeding state and dark/light cycle. Exp Biol Med (Maywood). 2003; Nov;228(10):1124-31.

Gu W, Geddes B, Zhang C, Foley K and Stricker-Krongrad A. The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice. J Mol Neurosci. 2004; Feb-Apr;22(1-2):93-103.

Perreault M, Istrate N, Wang L, Tozzo S and Stricker-Krongrad A. Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal after weight loss. International Journal of Obesity. 2004 July;28(7):879-885.

Kim JK, Gimeno RE, Higashimori T, Kim HJ, Choi H, Punreddy S, Mozell RL, Tan G, Stricker-Krongrad A., Hirsh DJ, Fillmore JJ, Liu ZX, Dong J, Cline G, Stahl A, Lodish HF and Schulman GI. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. JCI. 2004 March;113(5):756-763.

Beck B, Max JP, Richy S and Stricker-Krongrad A. Feeding response to a potent prolactin-releasing peptide agonist in lean and obese Zucker rats. Brain Res. 2004 July;1016(1):135-138.

Babic A, Lai M, Wang H, Daniels T, Felbinger T, Burger P, Stricker-Krongrad A. and Wagner D. Leukocyte adhesion through ICAM-1 and b2 integrin regulates fat oxidation and insulin clearance during fasting. Molecular Medicine 2004 Dec 3

Beck B, Richy S, Stricker-Krongrad A. Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats. Life Sci. 2004 Dec 10;76(4):473-8.

Stricker-Krongrad A., Beck B. Up-regulation of neuropeptide Y receptors in the hypothalamus of monosodium glutamate-lesioned Sprague-Dawley rats. Nutr Neurosci. 2004 Aug;7(4):241-5.

Robarge MJ, Bom DC, Tumey LN, Varga N, Gleason E, Silver D, Song J, Murphy SM, Ekema G, Doucette C, Hanniford D, Palmer M, Pawlowski G, Danzig J, Loftus M, Hunady K, Sherf BA, Mays RW, Stricker-Krongrad A., Brunden KR, Harrington JJ, Bennani YL. Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1749-53.

Song J, Doucette C, Hanniford D, Hunady K, Wang N, Sherf B, Harrington JJ, Brunden KR, Stricker-Krongrad A. Generation of cell lines for drug discovery through random activation of gene expression: application to the human histamine H3 receptor. Assay Drug Dev Technol. 2005 Jun;3(3):309-18.

Anderson JT, Ting AE, Boozer S, Brunden KR, Crumrine C, Danzig J, Dent T, Faga L, Harrington JJ, Hodnick WF, Murphy SM, Pawlowski G, Perry R, Raber A, Rundlett SE, Stricker-Krongrad A, Wang J, Bennani YL. Identification of novel and improved antimitotic agents derived from noscapine. J Med Chem. 2005 Nov 17;48(23):7096-8.

Murphy SM, Palmer M, Poole MF, Padegimas L, Hunady K, Danzig J, Gill S, Gill R, Ting A, Sherf B, Brunden K, Stricker-Krongrad A. Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel. J Pharmacol Toxicol Methods. 2006 Jul-Aug;54(1):42-55.

Song J, Hanniford D, Doucette C, Graham E, Poole MF, Ting A, Sherf B, Harrington J, Brunden K, Stricker-Krongrad A. Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes. Assay Drug Dev Technol. 2005 Dec;3(6):649-59.

Huck BR, Llamas L, Robarge MJ, Dent TC, Song J, Hodnick WF, Crumrine C, Stricker-Krongrad A, Harrington J, Brunden KR, Bennani YL. The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2891-4.

Hubbard B, Doege H, Punreddy S, Wu H, Huang X, Kaushik VK, Mozell RL, Byrnes JJ, Stricker-Krongrad A, Chou CJ, Tartaglia LA, Lodish HF, Stahl A, Gimeno RE. Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology. 2006 Apr;130(4):1259-69.

Huck BR, Llamas L, Robarge MJ, Dent TC, Song J, Hodnick WF, Crumrine C, Stricker-Krongrad A, Harrington J, Brunden KR, Bennani YL. The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4130-4.

Beck B, Richy S and Stricker-Krongrad A. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr Neurosci. 2007 Oct-Dec;10(5-6):211-4.

Sani SN, Henry K, Bohlke M, Kim J, Stricker-Krongrad A, Maher TJ. The effects of drug transporter inhibitors on the pharmacokinetics and tissue distribution of methotrexate in normal and tumor-bearing mice: a microdialysis study. Cancer Chemother Pharmacol. 2009 Oct 9. [Epub ahead of print]