- Human
Prostate cancer (LnCaP) cell line
- Proprietary Immunomodulation of BRM ru/ru nude
rat (SuperNude)
- Implanted into prostate of SuperNude/BRM
rat strain (Athymic and lyp insert)
- Readouts: thru
8 weeks, Body Weight, Tumor Size at Necropsy and
Histopathology relative to time
post treatment
Timeline 
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 Protocol:
- Athymic male nu rats (90+ days)
- Group Size n=6
- Pre-treatment
- Proprietary Treatment (Day -6, -4, and -2)
- Survival Surgery (Day 1): inject 106 LnCaP
cells, left ventral prostate lobe
- Treatment Groups (2x weekly, Days 14-28)
- Doxorubicin 5mg/kg, IV
- Suramin 10mg/kg, IV
- Doxorubicin + Suramin, IV
- vehicle
- Analyses
- Clinical: body weight and serum PSA, weekly
- Terminal: Tumor Weight and Histopathology
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