Christian Grant, Ph.D.

Professional Summary:

Dr. Grant is a Research Director at BRM who has 8+ years of experience in virology, molecular biology, and immunology working in the area of autoimmunity, with a focus on type 1 diabetes through our Type 1 Diabetes - Rapid Access to Intervention Development (T1D-Raid) governmental contract, as well as study directing contract research projects. Dr. Grant received his Ph.D. from Pennsylvania State University College of Medicine in Microbiology and Immunology in 2004 for his work on regulation of retroviral and cellular gene expression in antigen presenting cells. Prior to BRM, he was a National Institutes of Health National Institute of Neurological Disorders and Stroke (NIH/NINDS) postdoctoral fellow, working on several projects including the examination of Transforming Growth Factor-Beta (TGFβ) signaling and regulatory and effector T cell function in patients with human T lymphotropic virus type I (HTLV-I)-associated myelopathy and patients with multiple sclerosis. Dr. Grant’s research at NIH was funded by a prestigious NINDS Competitive Postdoctoral Fellowship Award.

Publications:

Grant C, Oh U, Griffith C, Yao K, Maric DA, Jacobson S. Cloning and functional characterization of the human Foxp3 promoter. In preparation.

Ratner L, Harrington W, Feng X, Grant C, Jacobson S, Noy A, Sparano J, Lee J, Ambinder R, Campbell N, Lairmore M, AIDS Malignancy Consortium. Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma. PLoS ONE, 2009;4:e4420.

Enose-Akahata Y, Oh U, Grant C, and Jacobson S. Retrovirrally-induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I associated neurologic disease. Blood. 2008; 112:2400-2410.

Fugo K, Grant C, and Jacobson S. HTLV-I/II. Neuroimmune Pharmacology. Gendelman HE and Ikezu T (eds). 2008; 313-326

Grant C, Oh U, Yamano Y, Yao K, Jacobson S. Dysregulation of TGF-beta signaling and regulatory and effector T cell function in virus-induced neuroinflammatory disease. Blood. 2008; 111:5601-9

Ratner L, Grant C, Zimmerman B, et al. Effect of treatment of Strongyloides infection on HTLV-I expression in a patient with Adult T-cell leukemia. American Journal of Hematology. 2007; 82:929-931.

Grant C, Jain P, Nonnemacher M, Flaig KE, Irish B, Ahuja J, Alexaki A, Alefantis T, Wigdahl B. AP-1-directed human T cell leukemia virus type I viral gene expression during monocytic differentiation. Journal of Leukocyte Biology. 2006; 80:640-650.

Yao J*, Grant C*, Harhaj E, Nonnemacher M, et al. Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III. DNA and Cell Biology. 2006; 25:262-276. *Contributed equally.

Grant C, Nonnemacher M, Jain P, et al. CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type I long terminal repeat activation. Virology. 2006; 348:354-369.

Oh U, Grant C, Griffith C, Fugo K, Takenouchi N, Jacobson S. Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 infection. Journal of Infectious Disease. 2006; 193:1557-1566.

Grant C, Oh U, Fugo K, Takenouchi et al. Foxp3 represses retroviral gene transcription by targeting both NF-kappaB and CREB pathways. PLoS Pathogens. 2006; 2:e33.

Yamano Y, Takenouchi N, Li HC, Tomaru U, Yao K, Grant CW, Maric DA, Jacobson S. Virus-induced dysfunction of CD4(+)CD25(+) T cells in patients with HTLV-I-associated neuroimmunological disease. Journal of Clinical Investigation. 2005; 115(5):1361-1368.

Harhaj EW, Harhaj NS, Grant C, et al. Human T cell leukemia virus type I tax activates CD40 gene expression via the NF-kappa B pathway. Virology. 2005; 333:145-158.

Alefantis T, Mostoller K, Jain P, Harhaj E, Grant C, Wigdahl B. Secretion of the human T cell leukemia virus type I transactivator protein tax. Journal of Biological Chemistry. 2005; 280:17353-17362.

Alefantis T, Barmak K, Harhaj EWK, Grant C, Wigdahl B. Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax. Journal of Biological Chemistry. 2003; 278:21814-21822.

Barmak K, Harhaj E, Grant C, Alefantis T, Wigdahl B. Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration. Virology. 2003;308:1-12.

Quiterio S, Grant C, Hogan TH, Krebs FC, Wigdahl B. C/EBP- and Tat-mediated activation of the HIV-1 LTR in CD34(+) hematopoietic progenitor cells. Biomedical Pharmacotherapy. 2003; 57:49-56.

Grant C, Barmak K, Alefantis T, Yao J, Jacobson S, Wigdahl B. Human T cell leukemia virus type I and neurologic disease: Events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation. Journal of Cellular Physiology. 2002; 190:133-159.

Alleva DG, Pavlovich RP, Grant C, Kaser SB, Beller DI. Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice. Diabetes. 2000; 49: 1106-1115.