Christopher Ace, Ph.D.

Professional Summary:

Dr. Ace, Study Director at BRM, is investigating a process towards "A Muscosal Vaccine for HSV-2" (Principal Investigator Kejian Yang), and study directing contract research projects. Dr. Ace received his Ph.D. in Molecular Virology from Glasgow University, UK, in 1989 for his thesis on the construction and characterization of a herpes simplex virus mutant deficient for VMW65 - mediated stimulation of immediate early gene transcription. He completed his Postdoctoral fellowships at Harvard Universityon the identification and characterization of factors controlling gene expression, and at the University of Massachusetts Medical School (UMMS) on the identification of progesterone-regulated genes involved in proper maturation of the primate endometrium. Prior to BRM, Inc. he was employed for 14 years in the Department of OB/GYN/Physiology at UMMS.

Publications:

Ace CI, Okulicz WC. Identification of progesterone-induced mRNA regulatory patterns in the Rhesus monkey endometrium by differential display reverse-transcription-polymerase chain reaction. Biol Reprod. 1999; 60:1029-1035.

Ace CI, Okulicz WC. A progesterone-induced endometrial homolog of a new candidate tumor-suppressor (DMBT1). Journal of Clinical Endocrinology and Metabolism. 1999; 83:3569-3573.

Ace CI, Merithew EL, Okulicz WC. Autologous down-regulation of mRNAs by progesterone in the primate endometrium. Molecular Biology of the Cell. 1997; 8 Supplement: 317a.

Okulicz WC, Balsamo M, Ace CI, Tast J. Zonal changes in proliferation in the rhesus endometrium during the late secretory phase and menses. Proceedings of the Society for Experimental Biology and Medicine. 1997; 214:132-138.

Okulicz WC, Ace CI. Isolation of cDNA fragments regulated by progesterone from rhesus monkey endometrium by differential display RT-PCR. Molecular Biology of the Cell. 1997; 7 Supplement: 472a.

Okulicz WC, Ace CI, Longcope C, Tast J. Analysis of differential gene regulation in adequate versus inadequate secretory-phase endometrial complementary deoxyribonucleic acid populations from the rhesus monkey. Endocrinology. 1996; 137:4844-4850.

Ace CI, Okulicz WC. Differential gene regulation by estrogen and progesterone in the primate endometrium determined by reverse transcription-polymerase chain reaction. Molecular and Cellular Endocrinology. 1995; 115:95-103.

Ace CI, Balsamo M, Le LT, Okulicz WC. Isolation of progesterone-dependent cDNAs from rhesus monkey endometrium by sequential subtractive hybridization and PCR analysis. Endocrinology. 1994; 134:1305-1309.

Lamaigre FP, Ace CI, Green MR. The cAMP response element binding protein CREB is a potent inhibitor of diverse transcriptional activators. Nucleic Acids Research. 1993; 21:2907-2911.

DeVito WJ, Avakian C, Stone S, Ace CI. Estradiol increases prolactin synthesis and prolactin messenger ribonucleic acid in selected brain regions in the hypophysectomized female rat. Endocrinology. 1992; 131:2154-2160.

Valyi-Nagy T, Deshmane SL, Spivack JG, Steiner I, Ace CI, Preston CM, and Fraser NW. Investigation of herpes simplex virus type I (HSV-1) gene expression and DNA synthesis during the establishment of latent infection by an HSV-1 mutant, in 1814, that does not replicate in mouse trigeminal ganglia. Journal of General Virology. 1991; 72:641-649.

Steiner I, Spivack JG, Deshmane SL, Ace CI, Preston CM, Fraser NW. A herpes simplex type 1 mutant contains a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia. Journal of Virology. 1990; 64:1630-1638.

Ace CI, McKee TA, Ryan JM, Cameron JM, Preston CM. Construction and characterization of a herpes simplex type 1 mutant unable to transinduce immediate, early gene expression. Journal of Virology. 1989; 63:2260-2269.

Ace CI, Dalrymple MA, Ramsay FH, Preston VG, Preston CM. A mutational analysis of the herpes simplex 1 transinducing factor Vmw65. Journal of General Virology. 1989; 69:2595-2605.