Dennis L. Guberski

Professional Summary:

Mr. Guberski, a geneticist, is the founder and CEO of BRM. He spent more than 20 years at the University of Massachusetts Medical School, both as a researcher and as Director of the SPF vivarium in the Department of Pathology, and in the process became an internationally recognized expert on the development and maintenance of specialized research models including a premier system to study diabetic complications. He currently serves as the Principal Investigator on the Type 1 Diabetes Rapid Access to Intervention Development (T1D Raid) government contract having previously served as PI on numerous National Institutes of Health (NIH) grants including projects elucidating the pathogenesis of type 1 diabetes, mapping susceptibility genes for type 1 diabetes and rheumatoid arthritis and developing novel models for environmental initiation of autoimmunity. Mr. Guberski was selected by NIH to participate in a taskforce to develop a National Genetic Resource Repository for laboratory rats and served as a member of the scientific review board for the NIH Autoimmune Rat Repository in Bethesda, Maryland. He received his MS in Genetics from University of Massachusetts, Amherst, MA.

Publications:

Tirabassi RS, Guberski DL, Blankenhorn EP, Leif JH, Woda BA, Liu Z, Winans D, Greiner DL, Mordes JP. Infection with viruses from several families triggers autoimmune diabetes in LEW.1WR1 rats: Prevention of Diabetes by Maternal Immunization. Diabetes. 2009; Sep 30 Epub ahead of print

Blankenhorn EP, Cort L, Greiner DL, Guberski DL, Mordes JP. Virus-Induced autoimmune diabetes in the LEW.1WR1 Rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex. Diabetes. 2009; Aug 31 Epub ahead of print

Li Q, Hwang YC, Ananthakrishnan R, Oates PJ, Guberski DL, Ramasamy R. Polyol pathway and modulation of ischemia-reperfusion injury in Type 2 diabetic BBZ rat hearts. Cardiovasc Diabetol. 2008; 7:33.

Yang K, Whalen BJ, Tirabassi RS, Selin LK, Levchenko TS, Torchilin VP, Kislauskis EH, Guberski DL. A DNA vaccine prime followed by a liposome-encapsulated protein boost confers enhanced mucosal immune responses and protection. J Immunol. 2008; 180(9):6159-67.

Jarajapu YP, Guberski DL, Grant MB, Knot HJ. Myogenic tone and reactivity of cerebral arteries in type II diabetic BBZDR/Wor rat. Eur J Pharmocol. 2008; 579 (1-3):298-307.

Caballero S, Sengupta N, Afzal A, Chang KH, Li Calzi S, Guberski DL, Kern TS, Grant MB. Ischemica vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells. Diabetes. 2007; 56(4):960-7.

Ito I, Jarajapu YP, Guberski DL, Grant MB, Knot HJ. Myogenic tone and reactivity Of rat ophthalmic artery in acute exposure to high glucose and in a type II diabetic model. Invest Ophtalmol Vis Sci. 2006; 47(2):683-692.

Mordes JP, Guberski DL, Leif JH, Woda BA, Flanagan JF, Greiner DL, Kislauskis EH, Tirabassi RS. LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation. Diabetes. 2005; 54(9):2727-2733.

Tirabassi RS, Flanagan JF, Wu T, Kislauskis EH, Birckbichler PJ, Guberski DL. The BBZDR/Wor Rat Model for Investigating the Complications of Type 2 Diabetes Mellitus. ILAR Journal. 2004; 45(3):292-302.

Ellis EA, Guberski DL, Huston B, Grant MB. Time course of NADH oxidase,inducible nitric oxide synthase and peroxynitrite in diabetic retinopathy in the BBZ/Wor rat. Nitric Oxide. 2002; 6(3):295-304.

Sima AAF, Zhang W, Xu G, Sugimoto K, Guberski DL, Yorek MA. A comparison of diabetic polyneuropathy in type II BBZDR/Wor rats and in type 1 BB/Wor rats. Diabetologia. 2000; 43(6):786-93.

Mordes JP, Bortell R, Guberski DL, Rossini AA, Greiner DL. Autoimmune diabetes mellitus in the BB rat. In: Sima AAF, Shafrir E, eds. Frontiers in animal diabetes research, Primer on animal models of diabetes. Reading, UK: Hardwood Academic Publishers; 1-41.

Ellis EA, Guberski DL, Somongy-Mann M, Grant MB. Increased H2O2 , vascular endothelial growth factor and receptors in the retina of BBZ/Wor diabetic rat. Free Radical in Biology and Medicine. 2000; 28(1):91-101.

Ellis EA, Grant MB, Murray FT, Wachowski MB, Guberski DL, Kubilis PS, Lutty GA. Increased NADH oxidase activity the Retina of BBZ/Wor Diabetic Rat. Free Radic Biol Med. 1998; 24(1):111-20.

Ellerman KE, Richards CA, Guberski DL, Shek WR, Like AA. Kilham rat triggers T Cell-dependent atoimmune diabetes in multiple strains of rat. Diabetes. 1996; 45(5):557-62.

Awata T, Guberski DL, Like AA. Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II. Endocrinology. 1995; 136(12):5731-5735.

Stubbs M, Guberski DL, Like AA. Preservation of GLUT 2 expression in islet beta cells of Kilham rat virus (KRV)-infected diabetes-resistant BB/Wor rats. Diabetologia. 1994; 37(12):1186-1194.

Guberski DL. Diabetes-prone and diabetes-resistant BB rats: animal models of spontaneous and virally induced diabetes mellitus, lymphocytic thyroiditis, and collagen-induced arthritis. ILAR News. 1993; 35(2):29-37.

Guberski DL, Butler L, Manzi SM, Stubbs M, Like AA. The BBZ/Wor rat: clinical characteristics of the diabetic syndrome. Diabetologia. 1993; 36(10):912-919.

Ellerman KE, Guberski DL, Like AA. A Viral Trigger for Autoimmune Diabetes: Hypothesis No More. In: Shafrir E, ed. Lessons from animal Diabetes IV. E.London: Smith-Gordon; 1992:61-64.

Like AA, Guberski DL, Butler L. Influence of environmental viral agents on frequency and tempo of diabetes mellitus in BB/Wor rats. Diabetes. 1991; 40:259-262.

Guberski DL, Thomas VA, Sheck WR, Like AA, Handler ES, Rossini AA, Wallace JE, Welsh RM. Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor Rats. Science. 1991; 254(5034):1010-1013.

Guberski DL, Butler L, Wallace JE, Like AA. The BBZ/Wor rat: Pancreatic beta cells of obese rats are more susceptible to immune destruction than beta cells of lean rats. In: Shafrir E, ed. Frontiers in Diabetes Research: Lessons from animal diabetes III. London: Smith Gordon & Co., Ltd.; 1990: 215-218.

Butler L, Guberski DL, Like AA. Changes in penetrance and onset of spontaneous diabetes in the BB/Wor rat. In: Shafrir E, ed. Frontiers in Diabetes Research: Lessons from animal diabetes III. London: Smith Gordon & Co., Ltd.; 1990: 50-53.

Guberski DL, Butler L, Kastern W, Like AA. Genetic studies in inbred BB/Wor rats: Analysis of progeny produced by crossing lymphopenic diabetes-prone with non lymphopenic diabetic rats. Diabetes. 1989; 38:887-893.

Guberski DL, Butler L, Like AA. The BBZ/Wor rat: an obese animal model with autoimmune diabetes. In: Shafrir E, Renold AE, eds. Frontiers in Diabetes Research: Lessons from Animal Diabetes II. London: John Libbey & Co., Ltd.; 1988: 268-272.

Butler L, Guberski DL, Like AA. Genetics of diabetes production in the Worcester colony of the BB rat. In: Shafrir E, Renold AE, eds. Frontiers in Diabetes Research: Lessons from Animal Diabetes: II. London: John Libbey & Co., Ltd.; 1988: 74-78.

Cohen AJ, McGill PD, Rosetti RG, Guberski DL, Like AA. Glomerulopathy in spontaneously diabetic rat: impact of glycemic control. Diabetes. 1987; 36:944-951.

Like AA, Guberski DL, Butler L. Diabetic BioBreeding/Worcester (BB/Wor) rats need not be lymphopenic. J.Immunol. 1986; 136:3254-3258.

Like AA, Biron CA, Weringer EJ, Byman K, Sroczynski E, Guberski DL. Prevention of diabetes in Biobreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells. J.Exp.Med. 1986; 164:1145-1159.

Like AA, DiRodi V, Thomas S, Guberski DL, Rossini. Prevention of diabetes mellitus in the BB/W rat with cyclosporin-A. Am.J.Pathol. 1984; 117:92-97.

Like AA, Anthony M, Guberski DL, Rossini AA.4. Spontaneous diabetes mellitus in the BB/W rat. Effects of glycocorticoids, Cyclosporin-A, and antiserum to rat lymphocytes. Diabetes. 1983; 32:326-330.

Butler L, Guberski DL, Like AA. The effect of inbreeding on the BB/W diabetic rat. Metabolism. 1983; 32:51-53.

Butler L, Guberski DL, Like AA. Genetic analysis of the BB/W diabetic rat. Canad.J.Genet.Cytol. 1983; 25:7-15.

Like AA, Rossini AA, Guberski DL, Appel MC, and Williams RM. Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with anti-serum to rat lymphocytes. Science. 1979; 206:1421-1423.