BRM provides the BBZDR/Wor
rat model of type 2 diabetes and specializes in the
long-term animal models.
The BBZDR/Wor Rat is an established
model system used to study Type 2 diabetes and resulting
diabetic complications.
Lean
non-diabetic littermates, non-diabetic obese females
and obese diabetic males can all be provided for tightly
controlled, meaningful experiments.
The
BBZDR rat/Wor is an established model system used to
study Type 2 diabetes and resulting diabetic complications.
| |
Lean
Females |
Obese |
Lean Males |
| Incidence of Diabetes |
0%
(N=783) |
98%
(N=225) |
3%
(N=217) |
0%
(N=729)
|
| Age at Onset |
NA |
66.8 ± 2.7 |
72.1± 4.6 |
NA |
For more information,
visit our services area or contact us. |
- Shares MHC of Type 1 Rats
- Islets are Hyperplastic
- Diabetics have diminished GLUT-
2 transporters
- The recessive fa gene causes obesity
and insulin resistance.
- 95% of the males but less than 5% of
the females become hyperglycemic.
Our
highly qualified staff can design and implement experimental
protocols to test
the efficacy of compounds on diabetic complications,
including:
- atherosclerotic heart disease,
- retinopathy,
- neuropathy and nephropathy.
|
The
BBZDR/Wor Rat