TNBS-Induced Experimental Colitis

• Rectal administration of 2,4 6-trinitrobenzenesulfonic acid
• Model for inflammatory bowel disease composed of ulcerative colitis and Crohn's disease
• IBD results in chronic inflammation of bowel, ulcerogenesis and diarrhea
• Currently few treatment options
• (TNBS) is well established model of IBD
• Can be performed in rats or mice

Rat Colitis Timeline

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• Rheumatoid Arthritis
• Hashimoto's Thyroiditis
• Multiple Sclerosis
• Inflammatory Disease

Multiple Data Read-Outs

• In life observations
  • Body weight
  • Food and water intake
• Gross pathological changes in colon
  • Colon scoring index
• Histological changes in colon
• Total IBD Index Score
  • % body weight loss
  • Fecal Consistency
  • Fecal occult blood test