Joan F Flanagan, Ph.D.

Professional Summary:

Dr. Flanagan is Vice President for Contract Research and IACUC Chair at BRM. She has 7+ years of preclincal experience with small and large animal models in CRO setting from early discovery to safety with a focus on metabolic and inflammatory disease and expertise in in vivo pharmacology and model development. She received her Ph.D. in Biochemistry and Molecular Biology from the University of Massachusetts Medical School in 2001 performing her thesis work on the structure and function of the yeast SWI/SNF chromatin remodeling complex. She worked at Charles River Laboratories for 4.5 years as a Study Director. Dr. Flanagan previously worked 3 years for BRM as a Study Director in the grant and contract research areas of type 1 and type 2 diabetes.

Publications:

Flanagan JF, Sticker-Krongrad A. Progression of Dietary-Induced Insulin Resistance in Non-Human Primates: A One Year Study in Rhesus Monkeys. In preparation.

Flanagan JF, Shen S, Farquhar R, et al. Lipid Partitioning as a Marker of Insulin Resistance Correlated to Clinical Progression of Type 2 Diabetes Onset in the Zucker Diabetic Fatty (ZDF) Rat. In preparation.

Owens DR, Peterson RG, Yeh WK, Wang Y, Pritchett-Corning KR, Elder B, Clifford CB, Flanagan JF. The C57BL/6NCrl-Leprdb-lb Mouse: A New Model for Metabolic Syndrome. In preparation.

Mordes JP, Guberski DL, Leif JH, Woda BA, Flanagan JF, Greiner DL, Kislauskis EH, Tirabassi RS. LEW.1WR1 Rats Develop Autoimmune Diabetes Spontaneously and in Response to Environment Perturbation. Diabetes. 2005; 54:2727-2733.

Tirabassi RS, Flanagan JF, Wu T, Kislauskis EH, Birckbickler PG, Guberski DL. The BBZDR/Wor Rat Model for Investigating the Complications of Type 2 Diabetes Mellitus. ILAR. 2004; 45(3):292-302.

Smith CL, Horowitz-Scherer R, Flanagan JF, Woodcock CL, Peterson CL. Structural Analysis of the Yeast SWI/SNF Chromatin Remodeling Complex. Nature Structural Biology. 2003; 10(2):141-5.

Flanagan JF, Peterson CL. The Role for the Yeast SWI/SNF Complex in DNA Replication. Nucleic Acids Research. 1999; 27:2022-2028.