Kejian Yang, Ph.D.

Professional Summary:

Dr. Yang is Vice President of Virology and Vaccine at BRM with 20 years of experience in molecular virology, immunology and vaccinology. He specialized in animal models for viral pathogenesis research and vaccine development against a series of human viral diseases, such as various hepatitis viruses, Herpes Simplex Virus (HSV-2), measles virus, Respiratory syncytial virus (RSV), influenza virus, rotavirus, Yellow fever virus, Dengue virus, Lymphocytic Choriomeningitis Virus (LCMV) and human immunodeficiency virus (HIV). He has been the Principal Investigator on three Centers for Disease Control and Prevention (CDC) funded research grants and one phase-2 Small Business Innovation Research (SBIR) grant funded by National Institutes of Health (NIH) for developing mucosal vaccination strategies. Prior to BRM he was Research Director at the Oral Vaccine Institute and worked at Hybridon Inc. He received his Ph.D. in Microbiology from Chinese Academy of Preventive Medicine,China.

Publications:

Yang K, Whalen BJ, Tirabassi RS, Selin LK, Levchenko TS, Torchilin VP, Kislauskis EH, Guberski DL. A DNA vaccine prime followed by a liposome-encapsulated protein boost confers enhanced mucosal immune responses and protection. J Immunol. 2008;180:6159-67.

Yang K, Herrmann JE. Painted LT on mouse skin is immunogenic and capable to switch the profile induced by Rotavirus VP6 DNA vaccine given by gene gun. In preparation.

Fisher GM, Solt LA, Hastings WD, Yang K, et al. Splenic and peritoneal B-1 cells differ in terms of transcriptional and proliferative features that separate peritoneal B-1 from splenic B-2 Cells. Cell Immunol. 2001; 213(1):62-71.

Yang K, Wang S, Chang KO, et al. Immune responses and protection obtained with rotavirus VP6 DNA vaccines given by intramuscular injection. Vaccine. 2001; 19(23034):3285-3291.

Torres C, Yang K, Mustafa F, Robinson HL. DNA immunization: effect of secretion of DNA-expressed hemagglutinins on antibody responses. Vaccine. 1999; 18:805-814.

Yang K, Mustafa F, Valsamakis A, Santoro JC, Griffen DE, Robinson HL. Early studies on DNA-based immunizations for measles virus. Vaccine. 1997; 15(8):888-892.

Yang K, Ruan L, Sun Z, Lu R, Zhu J. Localization of one functional domain related to fusion promotion activity in measles virus hemagglutinin gene. Chinese Journal of Virology. 1996; 13(1):13-18.

Yang K, Ruan L, Zhu C, Sun Z, Lu R, Xu S, Zhu J. Construction of a recombinant vaccinia virus vaccine co-expressing measles virus (L4 strain) hemagglutinin and fusion genes as well as human IL2. Chinese Journal of Virology. 1996; 12(4):300-306.

Yang K, Ruan L, Lu R, Sun Z, Zhu C, Zhu J. Cloning, expression and immunogenicity of hemagglutinin gene of measles virus L4 strain. Chinese Journal of Virology. 1996; 12(3):227-234.