Colony Management Services

BRM has the Facilities and experienced staff to offer our clients cost effective solutions to rodent colony management.

Below is a list of services that BRM offers. BRM will work with all clients to formulate custom colony management protocols.

Transgenic Phenotyping (mouse)

Daily Health Monitoring/Phenotyping
Clinical Care of Affected Animals

Full Necropsy - 20 tissue cassettes ( ~50 tissues)
Fixed or frozen to specifications

*Gross and Histopathology
Includes a written review by Board Certified Veterinary Pathologist with a specialization in the discipline

Digital Photodocumentation and Photomicroscopy
Publication Quality

Metabolic Disease Phenotyping Includes:

Diabetes

• Steady-state Glucose
• Insulin ELISA
• Fasted Glucose/Insulin Tolerance Testing
• HbA1c Analysis*
• In-vivo acute (glucose/arginine) insulin secretion studies
• Ex-vivo glucose oxidation, lipolysis, and gluconeogenesis

*Dyslipidemia

• Lipid Profile - Cholesterol, triglycerides, HDL, LDL, VLDL

Obesity

• Food intake comparison
• Body mass composition analysis by necropsy
• Leptin/Ghrelin analysis
• Core body temperature

Metabolic Feeding Studies

• Pair-feeding studies
• Food consumption
• Liquid consumption
  * via subcontract agreement with a commercial anayltical laboratory