BRM produces the WAG
rnu/rnu rats in virus-antibody free (VAF) facilities. The WAG rnu/rnu rats are phenotypically hairless with
possible fine-sparse hair growth.
General usage for the model is immunology-based research.
Transplant adoption studies have used these WAG rnu/rnu
models.
Origin:
WAG rnu/rnu rat
WAG/Cpb rats obtained by the Diabetes Division at UMMS in 1991 From: Dr. P. de
Very, head of Central Animal Laboratory
Rijksinstituut Voor Volksgezondheid en Milieuhygiene
The Netherlands |
- The
rnu gene was obtained from Carahalton , UK (RT1c) and
backcrossed into WAG/CPB for about 12 generations
as of October 1991. At that time, there was still heterozygosity
in the RT7 locus.
- WAG rnu/rnu rats were bred by the Diabetes Division
of the University of Massachusetts Medical School.
- First
nude rats (3 male and 4 female) provided by Dennis
Guberski to Barbara Whalen June 1995.
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