Phase 1 Trials Efficacy

BRM technicians have tested the efficacy of compounds in the following models:

Diabetic models

• BBDP/Wor rats
• BBDR/Wor rats
• BBZDR/Wor rats
• NOD mice
• Db/db mice
• Streptozotocin-induced diabetes

Obese animals

• BBZDR/Wor rats
• Diet-induced mice and rats
• Ob/Ob mice
• ZDF rats

Inflammatory models

• Carrageenan-induced paw edema in the rat
  • Croton oil-induced ear edema in the rat
  • Rheumatoid arthritis
    • Collagen-induced in the rat
    • Transgenic mouse models
  • TNBS-induced irritable bowel syndrome in the rat
  • Experimental autoimmune encephalitis in the mouse

Hypophysectomized rats

Mouse models of autosomal polycystic kidney disease

Haloperidol-induced catalepsy

Vascular leak syndrome in SCID mice

Rat wound healing models

BRM performs a wide range of non-clinical laboratory studies that support new drug applications (NDAs) for permits regulated by the Food and Drug Administration (FDA).

Custom assays to evaluate the efficacy of your compound can be designed and implemented by trained BRM staff.

We can evaluate the effectiveness of your compound using our proprietary research models or other commercially available models.