- Rheumatoid
arthritis (RA) affects 1.2 million Americans, mostly
women
- Chronic, systemic inflammatory autoimmune
disease
- Many rodent models of disease including
induced and
spontaneous
| BB/Wor |
Well documented strain, RT1u “human-like” |
| LEW.1WR1 CIA |
Autoimmune model, RT1u “human-like” |
| DBA/1 or B1ORIII CIA |
Well documented, less IND needed
|
| C57BI/6 and backcross mAb LPS |
Rapid screening, Use of Transgenics |
| TNF a (Taconic) |
Genetic Model—No manipulation |
|
Multiple Read-outs
- Scoring of pannus formation (view
diagram)
- View Paw Volume Timeline
- Paw volume measurements:
(view diagram)
|
