Animal Models of Rheumatoid Arthritis

• Rheumatoid arthritis (RA) affects 1.2 million Americans, mostly women
• Chronic, systemic inflammatory autoimmune disease
• Many rodent models of disease including induced and
  spontaneous

Model	Benefits
BB/Wor	Well documented strain, RT1u “human-like”
LEW.1WR1 CIA	Autoimmune model, RT1u “human-like”
DBA/1 or B1ORIII CIA	Well documented, less IND needed
C57BI/6 and backcross mAb LPS	Rapid screening, Use of Transgenics
TNF a (Taconic)	Genetic Model—No manipulation

Multiple Read-outs

Scoring of pannus formation

Score	Condition
0	Normal
1	Mild Redness and swelling of the ankle or wrist, redness and swelling in individual digits.
2	Moderate Redness and swelling of ankle and wrist
3	Severe Redness and swelling of entire paw, including digits

Paw volume timeline:

• caliper
• plethysmometer

Paw volume measurements: