Type 2 Diabetes BBZDR/Wor Rat Model

BRM provides the BBZDR/Wor rat model of type 2 diabetes and specializes in the long-term animal models.

The BBZDR/Wor Rat is an established model system used to study Type 2 diabetes and resulting diabetic complications.

Lean non-diabetic littermates, non-diabetic obese females and obese diabetic males can all be provided for tightly controlled, meaningful experiments.

The BBZDR rat/Wor is an established model system used to study Type 2 diabetes and resulting diabetic complications.

The Model:

• Shares MHC of Type 1 Rats
• Islets are Hyperplastic
• Diabetics have diminished GLUT- 2 transporters
• The recessive fa gene causes obesity and insulin resistance.
• 95% of the males but less than 5% of the females become hyperglycemic.

Our highly qualified staff can design and implement experimental protocols to test the efficacy of compounds on diabetic complications, including:

• atherosclerotic heart disease,
• retinopathy,
• neuropathy and nephropathy.