BRM has multiple rat models of Type 1 Diabetes including spontaneous and
induced disease development. We have extraordinary experience managing
these animals’ complex medical care during both short and long-term
studies Our animal models are easily adapted for the testing of compounds
for a multitude of applications. They provide populations of genetically
uniform subjects that can be maintained under environmentally controlled
conditions.
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| BBDP/Wor |
PVG
PVG.RT1u PVG.R8
WAG
BBDR/Wor |
LEW.1.WR1
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The BB/Wor rat develops
spontaneous and viral-induced syndromes of autoimmune
diabetes mellitus, and is the best rat model of
human Type 1 diabetes.
Salient features
include:
- Genetic predisposition
- Abrupt onset of insulin dependent, ketosis- prone
diabetes
- Autoimmune destruction of pancreatic ß-cells.
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Other features of the BB/Wor
rat that identify it as the best rat model of human
IDDM include:
- Their inbred status (>75 generations of sib
matings)
- High (80-95%) incidence of diabetes among both genders.
- Average age of onset of diabetes at 70 days.
- All diabetes prone (DP) BB/Wor strains are severely
lymphopenic
The BBDP/Wor rats develop more
severe and more “human like” complications
of diabetes than NOD, STZ or alloxan models.
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Type
1 Diabetes (Insulin Dependent Diabetes Mellitus) IDDM